Sodium alginate oligosaccharides attenuate hypertension in spontaneously hypertensive rats fed a low-salt diet.
Clin Exp Hypertens
; 34(5): 305-10, 2012.
Article
en En
| MEDLINE
| ID: mdl-22690942
ABSTRACT
We investigated the effects of sodium alginate oligosaccharides (alginate) on the development of spontaneous hypertension in rats. Spontaneous hypertensive rats were treated with alginate for 7 weeks. Systolic blood pressure (SBP) and cardiovascular and kidney damage were assessed. Systolic blood pressure increased in SHRs and this elevation was attenuated with alginate treatment. The heart weight tended to decline. Alginate did not change plasma cholesterol levels or urinary sodium excretions. The slightly higher urinary protein excretion in SHRs was not changed with the treatment; however, morphologic glomerular damage was significantly attenuated. Sodium alginate oligosaccharide attenuates spontaneous hypertension in SHRs, and may help prevent early-stage kidney injury.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hemostáticos
/
Dieta Hiposódica
/
Alginatos
/
Hipertensión
Límite:
Animals
Idioma:
En
Año:
2012
Tipo del documento:
Article