Influence of anti-HBc positive organ donor in lung donor selection.
Arch Bronconeumol
; 48(9): 320-4, 2012 Sep.
Article
en En, Es
| MEDLINE
| ID: mdl-22709511
ABSTRACT
INTRODUCTION:
The risk of hepatitis B virus (HBV) transmission through donor organs with HBsAg(-) and anti-HBc(+) serology has not been extensively studied in lung transplantation. The objectives of this study are to ascertain the influence of the anti-HBc(+) on the acceptance of the lung for transplantation, to comment on the published literature and to suggest an algorithm for action.METHODS:
A survey conducted in the 7 Spanish lung transplantation teams. The updated search of the literature was performed using medical databases from 1994 to February 2012.RESULTS:
All of the teams vaccinate the lung recipients against HBV, although none quantify the anti-HBs titers. When given an anti-HBc(+) donor, 3 teams change their strategy one does not accept the offer, one selects the receptor from among patients in emergency status and another adds pharmacological prophylaxis. Only 3 publications refer to the serologic evolution of the receptors. At the moment there have been no reported cases of hepatitis B or HBsAg positivity post-transplant, but 4 out of the 50 anti-HBc(-) receptors changed to anti-HBc(+) in the follow-up.CONCLUSIONS:
The presence of anti-HBc in the donor influences the decision to accept a lung donor, although there is little information on its repercussions. To date, there has been no reported case of transmission of HBV, but post-transplant anti-HBc seroconversions have been described, which suggests contact with viral particles. Although rare, an anti-HBc(+) donor can harbor a hidden HBV infection. The risk of infection can be reduced with adequate anti-HBs titers or with appropriate pharmacological measures.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Pulmón
/
Selección de Donante
/
Hepatitis B
/
Anticuerpos contra la Hepatitis B
/
Antígenos del Núcleo de la Hepatitis B
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
/
Es
Año:
2012
Tipo del documento:
Article