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A strategy for promoting bone regeneration by inducible expression of 15-LOX-1.
Pang, Hao; Wu, Xue-hui; Xu, Jian-zhong.
  • Pang H; Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China.
Med Hypotheses ; 79(3): 413-4, 2012 Sep.
Article en En | MEDLINE | ID: mdl-22770909
Repairing large bone defects is a major orthopaedic problem, with current treatments being constrained by the regenerative capacity of human tissue. Current methods for repairing bone defects include osteogenesis, osteoconduction, osteoinduction, and tissue engineering; however, the cumulative effect of these methods is, as of yet, rather unsatisfactory. Recent research has demonstrated that knockout of the cell cycle inhibitor p21, which works as a switch to control regenerative capacity, can promote cell proliferation and appendage regeneration. The enzyme 15-lipoxygenase type 1 (15-LOX-1), which is involved in arachidonic and linoleic acid metabolism, has the potential to down-regulate the expression of p21. Therefore, we hypothesise that the construction of a new bone substitute that expresses 15-LOX-1 locally will promote osteoblast proliferation through inhibition of p21, resulting in an effective and inducible method for promoting bone regeneration.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regeneración Ósea / Araquidonato 15-Lipooxigenasa Límite: Humans Idioma: En Año: 2012 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regeneración Ósea / Araquidonato 15-Lipooxigenasa Límite: Humans Idioma: En Año: 2012 Tipo del documento: Article