[Preparation and in vitro release characteristics of pulsed-release tablets of Apocynum venetum].

ABSTRACT

OBJECTIVE: Using Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics. METHOD: The pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit The effect of formulation on pulsatile release of A. venetum was investigated. RESULT: The pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit. The delayed release time of the tablets was (5.0 +/- 0.5) h. CONCLUSION: The pulsatile release characteristics of A. venetum pulsatile release tablets were confirmed in vitro.