Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus.
PLoS Negl Trop Dis
; 6(7): e1724, 2012.
Article
en En
| MEDLINE
| ID: mdl-22802980
ABSTRACT
BACKGROUND:
Aedes albopictus, the Asian tiger mosquito, is a vector of several arboviruses including dengue and chikungunya, and is also a significant nuisance mosquito. It is one of the most invasive of mosquitoes with a relentlessly increasing geographic distribution. Conventional control methods have so far failed to control Ae. albopictus adequately. Novel genetics-based strategies offer a promising alternative or aid towards efficient control of this mosquito. METHODOLOGY/PRINCIPALFINDINGS:
We describe here the isolation, characterisation and use of the Ae. albopictus Actin-4 gene to drive a dominant lethal gene in the indirect flight muscles of Ae. albopictus, thus inducing a conditional female-specific late-acting flightless phenotype. We also show that in this context, the Actin-4 regulatory regions from both Ae. albopictus and Ae. aegypti can be used to provide conditional female-specific flightlessness in either species. CONCLUSION/SIGNIFICANCE:
With the disease-transmitting females incapacitated, the female flightless phenotype encompasses a genetic sexing mechanism and would be suitable for controlling Ae. albopictus using a male-only release approach as part of an integrated pest management strategy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Control de Mosquitos
/
Aedes
/
Vectores de Enfermedades
/
Vuelo Animal
Límite:
Animals
Idioma:
En
Año:
2012
Tipo del documento:
Article