Absolute bioavailability of himantane in rabbits.
Bull Exp Biol Med
; 153(2): 206-8, 2012 Jun.
Article
en En, Ru
| MEDLINE
| ID: mdl-22816084
ABSTRACT
Pharmacokinetic parameters of himantane and its metabolites in the blood plasma of rabbits were compared after single administration of himantane solution in a dose of 25 mg intravenously and 100 mg orally. It was established that the original substance is characterized by low absolute bioavailability (7.95%). Himantane is subjected to first-pass effect and is extensively metabolized in the liver to metabolites with m/z 266 and 250.
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Banco de datos:
MEDLINE
Asunto principal:
Adamantano
Límite:
Animals
Idioma:
En
/
Ru
Año:
2012
Tipo del documento:
Article