Secoiridoids from the stem barks of Fraxinus rhynchophylla with pancreatic lipase inhibitory activity.
Nat Prod Res
; 27(12): 1132-5, 2013.
Article
en En
| MEDLINE
| ID: mdl-22840217
ABSTRACT
Pancreatic lipase digests dietary fats by hydrolysis, which is a key enzyme for lipid absorption. Therefore, reduction of fat absorption by the inhibition of pancreatic lipase is suggested to be a therapeutic strategy for obesity. From the EtOAc-soluble fraction of the stem barks of Fraxinus rhynchophylla (Oleaceae), four secoiridoids such as ligstroside (1), oleuropein (2), 2"-hydroxyoleuropein (3) and hydroxyframoside B (4) were isolated. The inhibitory activity of these compounds on pancreatic lipase was assessed using porcine pancreatic lipase as an in vitro assay system. Compound 4 showed the strongest inhibition on pancreatic lipase, which followed by compounds 1-3. In addition, compound 4 exerted inhibitory effect on pancreatic lipase in a mixed mechanism of competitive and noncompetitive manner. Taken together, F. rhynchophylla and its constituents might be beneficial to obesity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Páncreas
/
Fraxinus
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Iridoides
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Inhibidores Enzimáticos
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Lipasa
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article