Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity.
J Infect Dis
; 207(9): 1457-61, 2013 May 01.
Article
en En
| MEDLINE
| ID: mdl-22869912
ABSTRACT
To investigate the role of viral load in the pathogenesis of hemorrhagic fever with renal syndrome, the Hantaan virus RNA load in plasma from 101 patients was quantiï¬ed, and the relationships between viral load and disease course, severity, and level of specific humoral immunity were analyzed. The viral load, detectable in 79 patients, ranged from 3.43 to 7.33 log10 copies/mL of plasma. In the early stage of disease, patients in severe/critical group were found to have higher viral loads than those in the mild/moderate group (5.90 vs 5.03 log10 copies/mL; P = .001), suggesting an association between Hantaan virus load and disease severity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Índice de Severidad de la Enfermedad
/
ARN Viral
/
Virus Hantaan
/
Carga Viral
/
Fiebre Hemorrágica con Síndrome Renal
Límite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2013
Tipo del documento:
Article