[Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy]. / Resposta histológica do miocárdio a diferentes esquemas imunossupressores em pacientes com cardiomiopatia dilatada e diagnóstico de miocardite biópsia endomiocárdica.
Arq Bras Cardiol
; 54(5): 319-22, 1990 May.
Article
en Pt
| MEDLINE
| ID: mdl-2288519
ABSTRACT
PURPOSE:
To analyse the histological evolution of endomyocardial biopsies from children with active myocarditis, submitted or not to immunosuppressive therapy. PATIENTS ANDMETHODS:
Four groups of patients were compared, clinically treated as follows group I--anticongestive drugs (4 patients); group II--prednisone (5 patients); group III--prednisone plus azathioprine (9 patients); group IV--prednisone and cyclosporine (5 patients).RESULTS:
No patient from group I presented any histological improvement during a mean period of 9 months, while evident histological improvement occurred in 25% of patients from group I, 67% from group III and 80% from group IV. The microscopical aspect of resolving myocarditis was only observed in patients from groups III and IV, after treatment.CONCLUSION:
The immunosuppressive therapy with azathioprine or cyclosporine plus prednisone leads to decrease of active myocarditis intensity in a higher proportion of cases than the treatment with only prednisone or no immunosuppressive drugs.
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Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Dilatada
/
Inmunosupresores
/
Miocarditis
/
Miocardio
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Pt
Año:
1990
Tipo del documento:
Article