Structure and mode of peptide binding of pheromone receptor PrgZ.
J Biol Chem
; 287(44): 37165-70, 2012 Oct 26.
Article
en En
| MEDLINE
| ID: mdl-22948145
ABSTRACT
We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.
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Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
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Feromonas
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Proteínas Bacterianas
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Proteínas Portadoras
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Enterococcus faecalis
Idioma:
En
Año:
2012
Tipo del documento:
Article