Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses.
J Am Chem Soc
; 134(37): 15285-8, 2012 Sep 19.
Article
en En
| MEDLINE
| ID: mdl-22963534
ABSTRACT
We describe the isolation of (-)-lomaiviticins C-E (6-8), elucidation of the complete absolute and relative stereochemistry of (-)-lomaiviticin A (1), the synthetic conversion of (-)-lomaiviticin C (6) to (-)-lomaiviticin A (1), and the first evidence that the dimeric diazofluorene of (-)-lomaiviticin A (1) plays a defining and critical role in antiproliferative activity.
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Banco de datos:
MEDLINE
Asunto principal:
Fluorenos
Idioma:
En
Año:
2012
Tipo del documento:
Article