Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery.
Molecules
; 17(9): 10791-800, 2012 Sep 10.
Article
en En
| MEDLINE
| ID: mdl-22964497
ABSTRACT
An investigation on biologically active secondary metabolites from the stem bark of Mesua beccariana was carried out. A new cyclodione, mesuadione, along with several known constituents which are beccamarin, 2,5-dihydroxy-1,3,4-trimethoxy anthraquinone, 4-methoxy-1,3,5-trihydroxyanthraquinone, betulinic acid and stigmasterol were obtained from this ongoing research. Structures of these compounds were elucidated by extensive spectroscopic methods, including 1D and 2D-NMR, GC-MS, IR and UV techniques. Preliminary tests of the in vitro cytotoxic activities of all the isolated metabolites against a panel of human cancer cell lines Raji (lymphoma), SNU-1 (gastric carcinoma), K562 (erythroleukemia cells), LS-174T (colorectal adenocarcinoma), HeLa (cervical cells), SK-MEL-28 (malignant melanoma cells), NCI-H23 (lung adenocarcinoma), IMR-32 (neuroblastoma) and Hep-G2 (hepatocellular liver carcinoma) were carried out using an MTT assay. Mesuadione, beccamarin, betulinic acid and stigmasterol displayed strong inhibition of Raji cell proliferation, while the proliferation rate of SK-MEL-28 and HeLa were strongly inhibited by stigmasterol and beccamarin, indicating these secondary metabolites could be anti-cancer lead compounds in drug discovery.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Clusiaceae
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Corteza de la Planta
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Descubrimiento de Drogas
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Neoplasias
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article