Associations between serotonin transporter polymorphisms and cognitive processing applying the Emo 1-back task.
Cogn Emot
; 27(3): 465-73, 2013.
Article
en En
| MEDLINE
| ID: mdl-23017007
ABSTRACT
Down regulation of serotonin transporter (5-HTT) expression has been associated with brain function and major depression. The aim of this study was to explore the allelic variation (short and long) of the 5-HTTLPR polymorphism in attention bias associated with top-down processing of emotion. One hundred sixty-two healthy participants underwent genotyping (5-HTTLPR), background interviews, psychological screening, and a computerised test session (The Emo 1-back task). Carriers of the short 5-HTTLPR alleles in the serotonin transporter gene (SLC6A4) demonstrated less accuracy in The Emo 1-back task when presented with successive images of sad or fearful faces, but not for happy or neutral emotional faces. The study suggests an association between 5-HTTLPR variation in the serotonin transporter gene and altered emotion processing.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cognición
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2013
Tipo del documento:
Article