Phenocopy of warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload.
J Pediatr Hematol Oncol
; 35(6): e265-8, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23018567
ABSTRACT
Neonatal chondrodysplasia punctata (CDP) is characterized by epiphyseal stippling and midfacial hypoplasia. CDP is usually inherited, but can be acquired because of maternal vitamin K deficiency. We describe an infant with CDP born to a teenager with sickle cell anemia and transfusional iron overload. The mother had severe liver fibrosis, elevated liver iron concentration (34 mg Fe/g), and coagulopathy, but no gestational use of warfarin. Fetal abnormalities were attributed to vitamin K deficiency secondary to liver dysfunction from iron toxicity. Treatment of iron overload among women with sickle cell anemia of childbearing potential is important to avoid possible CDP in newborns.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
/
Anomalías Inducidas por Medicamentos
/
Condrodisplasia Punctata
/
Sobrecarga de Hierro
/
Reacción a la Transfusión
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Año:
2013
Tipo del documento:
Article