Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants.
Vox Sang
; 104(3): 207-13, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23046429
ABSTRACT
BACKGROUND AND OBJECTIVES:
Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants.METHODS:
A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period 1, a transfusion was indicated for a platelet count of <50,000/ml in clinically stable neonates or <100,000/ml in bleeding or clinically unstable infants. In Period 2, the indications were restricted to <25,000/ml in clinically stable neonates, or <50,000/ml in newborns who were either on mechanical ventilation, subject to imminent invasive procedures, within 72 h following a seizure, or extremely premature and <7 days old. A count of <100,000/ml was indicated for bleeding or major surgery.RESULTS:
Periods 1 and 2 comprised 121 and 134 neonates, respectively. The rates of ventricular haemorrhage and intrahospital death were similar in both periods. The percentage of transfused infants, the odds of receiving a platelet transfusion, the mean platelet count before transfusion and the percentage of transfusions with a platelet count >50,000/ml were greater in Period 1. Among thrombocytopenic neonates, the percentage of transfused neonates and the number of transfusions were similar in both groups.CONCLUSION:
The restrictive guideline for platelet transfusions reduced the platelet count thresholds for neonatal transfusions without increasing the rate of ventricular haemorrhage.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Recuento de Plaquetas
/
Guías de Práctica Clínica como Asunto
/
Transfusión de Plaquetas
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Año:
2013
Tipo del documento:
Article