Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation.
Angew Chem Int Ed Engl
; 52(1): 325-30, 2013 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-23080482
ABSTRACT
In real time thrombin activation in vivo can be imaged in real time with ratiometric activatable cell penetrating peptides (RACPPs). RACPPs are designed to combine 1) dual-emission ratioing, 2) far red to infrared wavelengths for in vivo mammalian imaging, and 3) cleavage-dependent spatial localization. The most advanced RACPP uses norleucine (Nle)-TPRSFL as a linker that increases sensitivity to thrombin by about 90-fold.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombina
/
Péptidos de Penetración Celular
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article