Trans-cranial electrical stimulation attenuates abrupt morphine withdrawal in rats assayed by remote computerized quantification of multiple motor behavior indices.
Eur J Pharmacol
; 175(2): 187-95, 1990 Jan 10.
Article
en En
| MEDLINE
| ID: mdl-2311653
ABSTRACT
The goal of the present study was to assess the effects of trans-cranial electrical stimulation on the behavioral signs of the abrupt withdrawal syndrome of rats. However, this goal also necessitated the introduction of an experimental model measuring animal behavior for prolonged periods of time using a computerized animal activity monitoring system to quantify spontaneous motor activities associated with abstinence behavior. Comparable withdrawal severity was obtained by both the activity monitoring system and investigator observation of motor signs of abstinence behavior. Moreover, using this system we demonstrate a time-dependent effect of electrical stimulation in reducing the severity of various indices of motor hyperactivity associated with abrupt morphine withdrawal in rats.
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Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Estimulación Eléctrica
/
Dependencia de Morfina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
1990
Tipo del documento:
Article