High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.
J Neurosci
; 32(45): 15837-42, 2012 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-23136422
ABSTRACT
After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from transplanted human embryonic stem cells (hESCs) can drive endogenous neuronal network activity in CNS tissue is still lacking. Here, using multielectrode array recordings, we report activation of high-frequency oscillations in the ß and γ ranges (10-100 Hz) in the host hippocampal network via targeted optogenetic stimulation of transplanted hESC-derived neurons.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Embrionarias
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Células-Madre Neurales
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Hipocampo
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Neuronas
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Año:
2012
Tipo del documento:
Article