A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger.
Am J Trop Med Hyg
; 88(1): 138-143, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23208876
ABSTRACT
Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6-60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46-1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estado Nutricional
/
Azitromicina
/
Crecimiento
/
Antibacterianos
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Humans
País como asunto:
Africa
Idioma:
En
Año:
2013
Tipo del documento:
Article