Increased leucocyte apoptosis in transfused ß-thalassaemia patients.
Br J Haematol
; 160(3): 399-403, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23216540
ABSTRACT
This exploratory study assessed apoptosis in peripheral blood leucocytes (PBL) from ß-thalassaemia patients receiving chronic transfusions and chelation therapy (deferasirox or deferoxamine) at baseline, 1, 6, and 12 months. At baseline, thalassaemic PBLs presented 50% greater levels of Bax (BAX), 75% higher caspase-3/7, 48% higher caspase-8 and 88% higher caspase-9 activities and 428% more nucleosomal DNA fragmentation than control subjects. Only neutrophils correlated significantly with apoptotic markers. Previously, we showed that over the treatment year, hepatic iron declined; we now show that the ratio of Bax/Bcl-2 (BCL2), (-27·3%/year), and caspase-9 activity (-13·3%/year) declined in both treatment groups, suggesting that chelation decreases body iron and indicators of PBL apoptosis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Talasemia beta
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Apoptosis
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Leucocitos
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2013
Tipo del documento:
Article