Flavin-dependent enzymes in cancer prevention.
Int J Mol Sci
; 13(12): 16751-68, 2012 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-23222680
ABSTRACT
Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last decade, many papers concerning their structure, reaction mechanism and role in the cancer prevention were published. In our work, we provide a more in-depth analysis of flavin-dependent enzymes and their contribution to the cancer prevention. We present the actual knowledge about the glucosinolate synthesized by flavin-containing monooxygenase (FMO)(GS-OX1) and its role in cancer prevention, discuss the influence of mutations in FAD-dependent 5,10-methylenetetrahydrofolate reductase on the cancer risk, and describe FAD as an important cofactor for the demethylation of histons. We also present our views on the role of riboflavin supplements in the prevention against cancer.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Riboflavina
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Complejo Vitamínico B
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5,10-Metilenotetrahidrofolato Reductasa (FADH2)
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Monoaminooxidasa
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Proteínas de Neoplasias
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Neoplasias
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Límite:
Animals
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Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article