Bacteriolytic activity of human interleukin-2.
Biochemistry (Mosc)
; 77(11): 1312-4, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-23240569
ABSTRACT
In this paper we report the discovery of bacteriolytic activity of an immune system cytokine mediator, interleukin-2. Bacteriolytic activity of interleukin-2 was compared with a well-known bacteriolytic enzyme - chicken egg white lysozyme - by monitoring the lysis of the Gram-negative bacterium Escherichia coli, the Gram-positive coccus Micrococcus luteus, and the Gram-positive spore-forming bacillus Bacillus subtilis. It was found that interleukin-2 has greater specificity to the Gram-negative bacterium E. coli than does lysozyme. In contrast to chicken egg white lysozyme, interleukin-2 does not lyse the Gram-positive coccus M. luteus and the Gram-positive spore-forming bacillus B. subtilis. These results give a new understanding of the biological functions of interleukin-2, a regulatory protein that plays a role in oncological and infectious diseases.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interleucina-2
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article