Cyclooxygenase-1 mediated platelet reactivity in young male smokers.
Clin Appl Thromb Hemost
; 20(4): 371-7, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-23242413
ABSTRACT
BACKGROUND:
The purpose of this study is to investigate the acute and chronic effects of cigarette smoking on cyclooxygenase- 1(COX-1)-mediated platelet reactivity among cigarette smokers.METHODS:
The levels of collagen-induced platelet aggregation, platelet COX-1 activity, and expressions were compared between smokers and age-matched nonsmokers. In smokers, the acute effects of cigarette smoking were assessed by repeating these measurements an hour after smoking.RESULTS:
Twenty-five smokers and age-matched nonsmokers (all men; mean age, 29 years) were studied. Collagen-induced platelet aggregation and plasma/urinary thromboxane B2 (TXB2) and 11-dehydroxythromboxane B2 levels were higher in cigarette smokers compared to nonsmokers. Greater expression of platelet COX-1 was observed in smokers than in nonsmokers. Among smokers, collagen-induced platelet aggregation correlated positively with platelet volume and circulating nicotine and cotinine concentrations. The levels of plasma/urinary TXB2 were significantly increased an hour after cigarette smoking.CONCLUSION:
Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Fumar
/
Ciclooxigenasa 1
Límite:
Adult
/
Humans
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Male
Idioma:
En
Año:
2014
Tipo del documento:
Article