Dilation of human atria: increased diffusion restrictions for ADP, overexpression of hexokinase 2 and its coupling to oxidative phosphorylation in cardiomyocytes.
Mitochondrion
; 13(5): 399-409, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23268198
ABSTRACT
Cardiac energy metabolism with emphasis on mitochondria was addressed in atrial tissue from patients with overload-induced atrial dilation. Structural remodeling of dilated (D) atria manifested as intracellular accumulation of fibrillar aggregates, lipofuscin, signs of myolysis and autophagy. Despite impaired complex I dependent respiration and increased diffusion restriction for ADP, no changes regarding adenylate and creatine kinase occurred. We observed 7-fold overexpression of HK2 gene in D atria with concomitant 2-fold greater activation of mitochondrial oxygen consumption by glucose, which might represent an adaption to increased energy requirements and impaired mitochondrial function by effectively joining glycolysis and oxidative phosphorylation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
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Cardiomiopatía Dilatada
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Adenosina Difosfato
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Miocitos Cardíacos
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Hexoquinasa
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Mitocondrias
Límite:
Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2013
Tipo del documento:
Article