R1 and R2 * changes in the human placenta in response to maternal oxygen challenge.
Magn Reson Med
; 70(5): 1427-33, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23280967
ABSTRACT
PURPOSE:
Pregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen-enhanced MRI (R1 contrast) and BOLD MRI (R2 * contrast) have the potential to noninvasively investigate this oxygen environment at a range of gestational ages.METHODS:
Scanning was carried out at 1.5 T under maternal air and oxygen breathing in a single placental slice in 14 healthy pregnant subjects of gestational ages 21-37 weeks. We report R1 changes using a respiratory-triggered inversion recovery-turbo spin-echo sequence, which is sensitive to changes in PO2 , and R2 * changes using a breathhold multiple gradient-recalled echo sequence sensitive to changes in oxygen saturation.RESULTS:
Significant R1 increases (P < 0.005, paired t-test) and R2 * decreases (P < 0.0001, paired t-test) between air and oxygen breathing were demonstrated. ΔR1 decreased with gestational age (P < 0.0005, r = -0.835, Pearson correlation test). No significant effect of gestational age on R2 * change was observed.CONCLUSION:
The results demonstrate the feasibility of non-invasive investigation of placental oxygenation using MRI and the sensitivity of R1 oxygen-enhanced MRI to gestational age. The techniques have the potential to provide unique noninvasive biomarkers in compromised pregnancies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Placenta
/
Embarazo
/
Oximetría
/
Imagen por Resonancia Magnética
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Interpretación de Imagen Asistida por Computador
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article