[Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters].
Zhonghua Nan Ke Xue
; 18(10): 925-9, 2012 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-23297503
ABSTRACT
OBJECTIVE:
To investigate the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters.METHODS:
We collected 535 semen samples, assessed sperm DNA damage by sperm chromatin dispersion test, and analyzed the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters according to the WHO criteria.RESULTS:
Statistically significant differences were observed in sperm DNA damage among sperm-nucleoprotein transition, acrosin activity, sperm concentration and the percentage of grade a + b sperm (P < 0.01). Sperm DNA damage was positively correlated with age, sperm-nucleoprotein transition, sperm concentration and the percentage of grade d sperm (P < 0.01 or P < 0.05), but negatively correlated with acrosin activity (P < 0.001). Stepwise linear regression analysis demonstrated that age, sperm concentration, the percentage of grade d sperm, sperm-nucleoprotein transition and acrosin activity were independent variables related to the DNA fragmentation index (DFI). The abnormality rates of sperm-nucleoprotein transition, acrosin activity, sperm concentration and graded a + b sperm were significantly higher in the sperm DNA damage group (DFI > or = 30%) than in the normal control (DFI < 30%) (P < 0.01).CONCLUSION:
Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters, which may become another important independent parameter for the evaluation of sperm quality.
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Banco de datos:
MEDLINE
Asunto principal:
Espermatozoides
/
Daño del ADN
/
Acrosina
/
Infertilidad Masculina
/
Nucleoproteínas
Límite:
Adult
/
Humans
/
Male
Idioma:
Zh
Año:
2012
Tipo del documento:
Article