Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure.
Reprod Biol Endocrinol
; 11: 2, 2013 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-23320481
ABSTRACT
BACKGROUND:
Trophoblast cell (CTB) invasion into the maternal endometrium plays a crucial role during human embryo implantation and placentation. This invasion is facilitated by the activity of matrix metalloproteinases, which are regulated by tissue inhibitors of MMPs (TIMPs).METHODS:
This study compares the serum levels of MMP-9, MMP-2/TIMP-2 complex, TIMP-1 and TIMP-2 in 129 patients with ongoing pregnancy (n = 40) or spontaneous early pregnancy failure (n = 89).RESULTS:
MMP-9 was markedly (p < 0.0001) elevated in missed abortions, as was MMP-2/TIMP-2 complex (p < 0.0005). However, the serum levels of TIMP-1 and TIMP-2 were markedly elevated (p < 0.0001) in ongoing pregnancies.CONCLUSIONS:
Human placentation is mediated by fetal trophoblastic cells that invade the maternal uterine endometrium. Trophoblast invasion requires a precisely regulated secretion of specific proteolytic enzymes able to degrade the endometrial basement membrane and extracellular matrix. The elevated levels of MMP-9 and MMP-2/TIMP-2 complex may play a role in spontaneous termination of pregnancy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aborto Espontáneo
/
Inhibidor Tisular de Metaloproteinasa-1
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Inhibidor Tisular de Metaloproteinasa-2
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Metaloproteinasa 2 de la Matriz
/
Metaloproteinasa 9 de la Matriz
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
2013
Tipo del documento:
Article