TEM-187, a new extended-spectrum ß-lactamase with weak activity in a Proteus mirabilis clinical strain.
Antimicrob Agents Chemother
; 57(5): 2410-2, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23478954
ABSTRACT
A Proteus mirabilis clinical strain (7001324) was isolated from urine sample of a patient hospitalized in a long-term-care facility. PCR and cloning experiments performed with this strain identified a novel TEM-type ß-lactamase (TEM-187) differing by four amino acid substitutions (Leu21Phe, Arg164His, Ala184Val, and Thr265Met) from TEM-1. This characterization provides further evidence for the diversity of extended-spectrum ß-lactamases (ESBL) produced by P. mirabilis and for their potential spread to other Enterobacteriaceae due to a lack of sensitive detection methods used in daily practice.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteus mirabilis
/
Beta-Lactamasas
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Farmacorresistencia Bacteriana Múltiple
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Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article