A strain of Yersinia pestis with a mutator phenotype from the Republic of Georgia.
FEMS Microbiol Lett
; 343(2): 113-20, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23521061
ABSTRACT
We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y. pestis. The responsible mutation, a C to T substitution in the mutS gene, results in the transition of a highly conserved leucine at position 689 to arginine (mutS(L689R)). When the MutSL 689R protein of G1670A was expressed in a ΔmutS derivative of Y. pestis strain EV76, mutation rates observed were equivalent to those observed in G1670A, consistent with a causal association between the mutS mutation and the mutator phenotype. The observation of a mutator allele in Yersinia pestis has potential implications for the study of evolution of this and other especially dangerous pathogens.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fenotipo
/
Yersinia pestis
/
Mutación
País como asunto:
Europa
Idioma:
En
Año:
2013
Tipo del documento:
Article