Rodent models of amyotrophic lateral sclerosis.
Biochim Biophys Acta
; 1832(9): 1421-36, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23524377
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterised by the degeneration of upper and lower motor neurons. Recent advances in our understanding of some of the genetic causes of ALS, such as mutations in SOD1, TARDBP, FUS and VCP have led to the generation of rodent models of the disease, as a strategy to help our understanding of the pathophysiology of ALS and to assist in the development of therapeutic strategies. This review provides detailed descriptions of TDP-43, FUS and VCP models of ALS, and summarises potential therapeutics which have been recently trialled in rodent models of the disease. This article is part of a Special Issue entitled Animal Models of Disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Roedores
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Biomarcadores
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Terapia Genética
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Modelos Animales de Enfermedad
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Esclerosis Amiotrófica Lateral
Límite:
Animals
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Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article