Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis.
Rheumatol Int
; 10(1): 31-7, 1990.
Article
en En
| MEDLINE
| ID: mdl-2353151
ABSTRACT
Compared with normal cartilage, the water content, extraction yields, and capacity of 34SO4 incorporation, were found to be increased in articular cartilage from rheumatoid joints, which also synthesizes an increased proportion of low and middle density small size proteoglycans (PGs), enriched in dermatan sulfate. These small [35S]-PGs also possess longer glycosaminoglycan side chains and lack the ability to interact with hyaluronan. An altered pattern of PG synthesis of rheumatoid chondrocytes may contribute to cartilage damage in this condition.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Proteoglicanos
/
Cartílago Articular
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1990
Tipo del documento:
Article