Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission.
J Virol
; 87(11): 6507-11, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23536663
ABSTRACT
We report that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin (HA) of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that amino acids 200T and 227E are adaptive changes in the HA of swine origin influenza viruses associated with increased transmission and decreased pathogenesis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas Hemaglutininas del Virus de la Influenza
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Sustitución de Aminoácidos
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Gripe Humana
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Subtipo H1N1 del Virus de la Influenza A
Límite:
Animals
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Female
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Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article