Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model.
Amino Acids
; 45(1): 159-70, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23553487
ABSTRACT
N-Acylbenzotriazoles enable the synthesis (69-92% yield) of blue to green fluorescent coumarin-labeled depsidipeptides 8a-f (quantum yields 0.004-0.97) and depsitripeptides 12a-d (quantum yields 0.02-0.96). Detailed photophysical studies of fluorescent coumarin-labeled depsipeptides 8a-f and 12a-d are reported for both polar protic and polar aprotic solvents. 7-Methoxy and 7-diethylaminocoumarin-3-ylcarbonyl depsipeptides 8c,f and 12d are highly solvent sensitive. These highly fluorescent compounds could be useful for peptide assays. Further photophysical studies of 7-diethylaminocoumarin-labeled depsipeptides 8c,12d within the micellar microenvironment of SDS reflect their ability to bind with the biological membrane, suggesting potential applications in the fields of bio- and medicinal chemistry.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dodecil Sulfato de Sodio
/
Cumarinas
/
Depsipéptidos
/
Colorantes Fluorescentes
Idioma:
En
Año:
2013
Tipo del documento:
Article