Applications of nanosystems to anticancer drug therapy (Part II. Dendrimers, micelles, lipid-based nanosystems).
Recent Pat Anticancer Drug Discov
; 9(1): 99-128, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-23578193
ABSTRACT
The great efforts of many researchers have brought down some of the barriers that exist to turn a good in vitro compound into a potential in vivo drug. The advent of pharmaceutical nanotechnology has allowed an arsenal of drugs with poor stability, low solubility, high off-target toxicity and other disadvantageous features, to be accessible as pharmaceutical products that could be administered to a patient. Nanotechnology was introduced in drug delivery very long ago, but has flourished with unprecedented intensity during the last twenty years and now a diversity of nano-based preparations are at clinical stage of development or already available in the market. Undoubtedly, nanotechnology plays a key role in future pharmaceutical development and pharmacotherapy. In the first part of this review, we have already discussed recent (2008-2012) patents on linear polymer-based nanosystems (nanogels, nanospheres and nanocapsules) applications to cancer therapy. Here, we have expanded such analysis to branched polymers (dendrimers), self-assembling nanomicelles and lipid-based nanocarriers.
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Banco de datos:
MEDLINE
Asunto principal:
Nanotecnología
/
Dendrímeros
/
Nanopartículas
/
Micelas
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2014
Tipo del documento:
Article