A novel mutation in ABCC8 gene in a newborn with congenital hyperinsulinism -a case report.
Fetal Pediatr Pathol
; 32(6): 412-7, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23607867
ABSTRACT
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy. The genetic basis of CHI includes a variety of defects in key genes regulating insulin secretion. Mutations in at least seven genes are found in 50% of cases. The most common forms of medically unresponsive CHI, which requires a near-total pancreatectomy are associated with autosomal recessive mutations in the ABCC8 and KCNJ11 genes encoding the two subunits of the pancreatic ß-cell ATP-sensitive potassium channel. We report a neonate with CHI and have a novel homozygous splicing mutation in the ABCC8 gene.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hiperinsulinismo Congénito
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Receptores de Sulfonilureas
Tipo de estudio:
Etiology_studies
Límite:
Female
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Humans
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Infant
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Newborn
Idioma:
En
Año:
2013
Tipo del documento:
Article