Statistical power considerations for a utility endpoint in observer performance studies.
Acad Radiol
; 20(7): 798-806, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23611439
ABSTRACT
RATIONALE AND OBJECTIVES:
The purpose of this investigation is to compare the statistical power of the most common measure of performance for observer performance studies, area under the ROC curve (AUC), to an expected utility (EU) endpoint. MATERIALS ANDMETHODS:
We have modified a well-known simulation procedure developed by Roe and Metz for statistical power analysis in receiver operating characteristic (ROC) studies. Starting from a set of baseline simulations, we investigate the effects of three parameters that describe properties of the observers (iso-utility slope, unequal variance, and tendency to favor more aggressive or conservative actions) and three parameters that affect experimental design (number of readers, number of cases, and fraction of positive cases).RESULTS:
The EU endpoint generally has good statistical power relative to AUC in our simulations. Of 396 total conditions simulated, EU had higher statistical power in 377 cases (95%). In 246 of these cases, EU power was 5 percentage points or more higher than AUC. In simulation runs evaluating the effect of the number of readers and cases on the baseline simulations, EU measure had equivalent power to AUC with fewer readers (9% to 28%) or fewer cases (18% to 41%).CONCLUSION:
These simulation studies provide further motivation for considering EU in studies of screening mammography technology and they motivate investigations of utility in other diagnostic tasks.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Radiología
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Curva ROC
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Estadística como Asunto
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Modelos Estadísticos
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Año:
2013
Tipo del documento:
Article