Foamy virus Gag p71-p68 cleavage is required for template switch of the reverse transcriptase.
J Virol
; 87(13): 7774-6, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23616664
ABSTRACT
In contrast to orthoretroviruses, processing of foamy viral p71 Gag is limited to a single cleavage site. Nevertheless, Gag maturation is essential for infectivity, but deletion of p3 results in a modest drop in infectivity. Here, we show that Gag processing of p71 to p68 and p3 is essential for full-length cDNA synthesis, while inactivation of Gag cleavage results in cDNAs containing only the RU5 region; cDNAs encompassing the U3 region were almost undetectable.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Productos del Gen gag
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Procesamiento Proteico-Postraduccional
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Ácido Aspártico Endopeptidasas
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ADN Polimerasa Dirigida por ARN
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ADN Complementario
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Spumavirus
Idioma:
En
Año:
2013
Tipo del documento:
Article