Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.
J Biomed Nanotechnol
; 9(3): 511-5, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23621008
ABSTRACT
Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.
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Banco de datos:
MEDLINE
Asunto principal:
Poliuretanos
/
Sulfadiazina de Plata
/
Cicatrización de Heridas
/
Quemaduras
/
Andamios del Tejido
/
Nanofibras
/
Gelatina
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article