Circovirus in tissues of dogs with vasculitis and hemorrhage.
Emerg Infect Dis
; 19(4): 534-41, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23628223
ABSTRACT
We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vasculitis
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ADN Viral
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Genoma Viral
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Circovirus
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Infecciones por Circoviridae
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Diarrea
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Enfermedades de los Perros
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Hemorragia Gastrointestinal
País como asunto:
America do norte
Idioma:
En
Año:
2013
Tipo del documento:
Article