Late autoimmune hepatitis after hepatitis C therapy.
Eur J Gastroenterol Hepatol
; 25(11): 1308-11, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23628974
ABSTRACT
BACKGROUND:
De-novo or reactivated autoimmune hepatitis (AIH) has been reported during or a short time after administration of interferon (IFN) in patients treated for hepatitis C (HCV). Reports on AIH during long-term follow-up after IFN treatment are scarce. PATIENTS ANDMETHODS:
Patients diagnosed with both HCV and AIH were identified in clinical databases of four gastroenterology departments. The medical records of patients diagnosed with AIH after IFN therapy were retrospectively assessed.RESULTS:
Five patients (four female, one male) with a mean age of 50 years (range 34-59) were identified. AIH developed at a mean duration of 4.8 years (range 1-10) after HCV therapy. Three of five patients had a sustained viral response to antiviral therapy, whereas two were nonresponders. All patients were treated with immunosuppressive therapy after being diagnosed with AIH. Biochemical remission was achieved in four patients; however, one patient had an aggressive course and died despite immunosuppressive therapy. We could not identify any risk factors associated with the development of AIH.CONCLUSION:
AIH may develop in patients treated with IFN, not only during or after a short time from therapy but also after a long time from discontinuation of therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Interferones
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Hepatitis C
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Hepatitis Autoinmune
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Enfermedad Hepática Inducida por Sustancias y Drogas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Año:
2013
Tipo del documento:
Article