Efficient synthesis of dichlorodenafil, an unapproved sildenafil analogue appearing in non-prescription supplements.
Chem Pharm Bull (Tokyo)
; 61(5): 572-5, 2013.
Article
en En
| MEDLINE
| ID: mdl-23649199
ABSTRACT
We have developed an efficient synthesis of dichlorodenafil (4), an unapproved sildenafil analogue isolated from dietary supplements. Our sequence employs POCl(3)-mediated chlorination of readily available chloroacetyl compound 7 followed by selective hydrolysis of the chloro-heterocycle function. Our synthesis confirms the structure of the illegal additive, and will provide regulatory agencies with ready access to authentic standard samples of dichlorodenafil (4) to aid in their mission to protect the public from unapproved and potentially harmful erectile dysfunction (ED) drug analogues that are added to herbal and dietary supplements without providing users with appropriate toxicological or pharmacological information.
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Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Pirazoles
/
Pirimidinonas
/
Sulfonas
/
Suplementos Dietéticos
Idioma:
En
Año:
2013
Tipo del documento:
Article