Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensitivity occurrence in humans.
Toxicol Appl Pharmacol
; 271(1): 30-40, 2013 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-23651737
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inmunoglobulina E
/
Centro Germinal
/
Hipersensibilidad a las Drogas
/
Tejido Linfoide
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article