New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.
Bioorg Med Chem
; 21(13): 3839-49, 2013 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-23665142
ABSTRACT
A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their intermediate ketones and indomethacin. The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antiinflamatorios no Esteroideos
/
Donantes de Óxido Nítrico
/
Antineoplásicos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
2013
Tipo del documento:
Article