Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release.
Free Radic Res
; 47(8): 593-601, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23678888
ABSTRACT
Inflammation results in the production of free radicals. We evaluated the anti-inflammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-inflammatory properties. Our results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced Th1 lymphocytes-related cytokines by approximately 50-60%. Simultaneously, lipoic acid treatment caused a significant reduction in uveal histopathological grading and in the protein concentration in aqueous humors, but not in cellular infiltration.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Uveítis
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Antiinflamatorios no Esteroideos
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Citocinas
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Ácido Tióctico
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Células TH1
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Antioxidantes
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article