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iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein-protein interactions.
Labbé, Céline M; Laconde, Guillaume; Kuenemann, Mélaine A; Villoutreix, Bruno O; Sperandio, Olivier.
  • Labbé CM; Université Paris Diderot, Sorbonne Paris Cité, Molécules Thérapeutiques in silico, France; Inserm UMR-S 973, 39 rue Hélène Brion, 75205 Paris Cedex 13, France; CDithem, Faculté de Pharmacie, 1 rue du Prof Laguesse, 59000 Lille, France.
Drug Discov Today ; 18(19-20): 958-68, 2013 Oct.
Article en En | MEDLINE | ID: mdl-23688585
ABSTRACT
The development of small molecule drugs targeting protein-protein interactions (PPI) represents a major challenge, in part owing to the misunderstanding of the PPI chemical space. To this end, we have manually collected the structures, the physicochemical and pharmacological profiles of 1650 PPI inhibitors across 13 families of PPI targets in a database named iPPI-DB. To access iPPI-DB, we propose a user-friendly web application (www.ippidb.cdithem.fr) with customizable queries and intuitive visualizing functionalities for associated properties of the compounds. This could assist scientists to design the next generation of PPI drugs. In this review, we describe iPPI-DB in the context of other low molecular weight molecule databases.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azocinas / Compuestos de Bencidrilo / Sistemas de Liberación de Medicamentos / Mapeo de Interacción de Proteínas / Bases de Datos de Proteínas / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2013 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Azocinas / Compuestos de Bencidrilo / Sistemas de Liberación de Medicamentos / Mapeo de Interacción de Proteínas / Bases de Datos de Proteínas / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2013 Tipo del documento: Article