[From cannabis to selective CB2R agonists: molecules with numerous therapeutical virtues]. / Du cannabis aux agonistes sélectifs du récepteur CB2 - des molécules aux nombreuses vertus thérapeutiques.
Med Sci (Paris)
; 29(5): 523-8, 2013 May.
Article
en Fr
| MEDLINE
| ID: mdl-23732102
ABSTRACT
Originally used in Asia for the treatment of pain, spasms, nausea and insomnia, marijuana is the most consumed psychotropic drug worldwide. The interest of medical cannabis has been reconsidered recently, leading to many scientific researches and commercialization of these drugs. Natural and synthetic cannabinoids display beneficial antiemetic, anti-inflammatory and analgesic effects in numerous diseases, however accompanied with undesirable effects due to the CB1 receptor. Present researches focus on the design of therapeutical molecules targeting the CB2 receptors, and thus avoiding central side effects and therefore psychotropic effects caused by the CB1 receptor.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cannabinoides
/
Receptor Cannabinoide CB2
/
Agonistas de Receptores de Cannabinoides
Límite:
Humans
Idioma:
Fr
Año:
2013
Tipo del documento:
Article