DNA repair at telomeres: keeping the ends intact.
Cold Spring Harb Perspect Biol
; 5(6)2013 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-23732473
ABSTRACT
The molecular era of telomere biology began with the discovery that telomeres usually consist of G-rich simple repeats and end with 3' single-stranded tails. Enormous progress has been made in identifying the mechanisms that maintain and replenish telomeric DNA and the proteins that protect them from degradation, fusions, and checkpoint activation. Although telomeres in different organisms (or even in the same organism under different conditions) are maintained by different mechanisms, the disparate processes have the common goals of repairing defects caused by semiconservative replication through G-rich DNA, countering the shortening caused by incomplete replication, and postreplication regeneration of G tails. In addition, standard DNA repair mechanisms must be suppressed or modified at telomeres to prevent their being recognized and processed as DNA double-strand breaks. Here, we discuss the players and processes that maintain and regenerate telomere structure.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Telómero
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ADN Helicasas
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Proteínas de Unión a Telómeros
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Reparación del ADN
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Replicación del ADN
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Homeostasis del Telómero
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Modelos Biológicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article