Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces.
Adv Healthc Mater
; 3(1): 30-5, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-23788402
ABSTRACT
Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombomodulina
/
Aminas
Límite:
Animals
Idioma:
En
Año:
2014
Tipo del documento:
Article