Expression of hypoxia inducible factor-1α and vascular endothelia growth factor in vocal polyps.
Laryngoscope
; 123(9): 2184-8, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23821497
ABSTRACT
OBJECTIVES/HYPOTHESIS:
Long-term vocal overuse or sudden vocal-fold microvascular disruption may lead to the formation of a hypoxic zone of injury and the subsequent release of a cascade of cytokines in the vocal fold. To test this hypothesis, we investigated the expression and the role of hypoxia inducible factor-1α (HIF-1α) and vascular endothelia growth factor (VEGF) in the formation of vocal polyps.METHODS:
Expression patterns of HIF-1α and VEGF in surgical specimens of vocal polyps from 36 patients were analyzed using the immunohistochemistry and Western blot method. Normal vocal-fold mucosa from 26 patients who underwent total laryngectomy were collected and used as the control group.RESULTS:
The expression of HIF-1α and VEGF were detected both in the vocal polyps group and the control group, while the expression of HIF-1α and VEGF levels were significantly higher when compared to normal vocal-fold mucosa (P < .05).CONCLUSION:
The increased expression of HIF-1α in vocal polyps indicates that vocal fold overvibration induced hypoxia may play an important role in the pathogenetic mechanism of vocal polyps.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pólipos
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Pliegues Vocales
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Biomarcadores de Tumor
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Neoplasias Laríngeas
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Factor A de Crecimiento Endotelial Vascular
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Subunidad alfa del Factor 1 Inducible por Hipoxia
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2013
Tipo del documento:
Article