Liver X receptor α inhibits osteosarcoma cell proliferation through up-regulation of FoxO1.
Cell Physiol Biochem
; 32(1): 180-6, 2013.
Article
en En
| MEDLINE
| ID: mdl-23867395
ABSTRACT
BACKGROUND:
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults.METHODS:
We analyzed liver X receptor α (LXRα) mRNA expression in 16 pairs of human osteosarcoma tissues and adjacent noncancerous tissues. Moreover, we investigated LXRα's potential role in regulating cell proliferation in Saos-2 and U2OS cells.RESULTS:
We found that activation of LXRα, a member of nuclear receptor, was able to inhibit cell proliferation in Saos-2 and U2OS cells. At the molecular level, our results further revealed that expression of tumor suppressor gene, FoxO1, was up-regulated by LXRα activation. LXRα activates FoxO1 transcription through a direct binding on its promoter region.CONCLUSION:
LXRα acts as a tumor suppressor for osteosarcoma, which may offer a new way in molecular targeting cancer treatment.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción Forkhead
/
Receptores Nucleares Huérfanos
Límite:
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article